MEDICINE

A government designed to use public funds to pick winners and losers in the drug industry threatens human health. Only with the truth of science discoveries and honest reporting of drug efficacy can a physician offer hope for human recovery from curable diseases.

Books of Interest
 Website: chetyarbrough.blog

Rethinking Medications (Truth, Power, and the Drugs You Take)

By: Jerry Avorn

Narrated By: Jerry Avorn MD

Jerry Avorn (Author, professor of medicine at Harvard Medical School where he received his MD, Chief Emeritus of the Division of Pharmacoepidemiology and Pharmacoeconomics)

Doctor Avorn enlightens listener/readers about drug industry’ costs, profits, and regulation. Avorn explains how money corrupts the industry and the FDA while encouraging discovery of effective drug treatments. The cost, profits, and benefits of the industry revolve around research, discovery, medical efficacy, human health, ethics, and regulation.

Drug manufacture is big business.

Treatments for human maladies began in the dark ages when little was known about the causes of disease and mental dysfunction. Cures ranged from spirit dances to herbal concoctions that allegedly expelled evil, cured or killed its followers and users. The FDA (Food and Drug Administration) did not come into existence until 1930, but its beginnings harken back to the 1906 Pure Food and Drug Act signed into law by Theodore Roosevelt. The FDA took on the role of reviewing scientific drug studies for drug treatments that could aid health recovery for the public. The importance of review was proven critical by incidents like that in 1937, when 107 people died from a Sulfanilamide drug which was found to be poisonous. From that 1937 event forward, the FDA required drug manufacturers to prove safety of a drug before selling it to the public. The FDA began inspecting drug factories while demanding drug ingredient labeling. However, Avorn illustrates how the FDA was seduced by Big Pharma’ to offer drug approvals based on flawed or undisclosed research reports.

Dr. Martin Makary (Dr. Makary was confirmed as the new head of the FDA on March 25, 2025. He is the 27th head of the Department. He is a British-American surgeon and professor.)

What Dr. Avorn reveals is how the FDA has either failed the public or been seduced by drug manufacturers to approve drugs that have not cured patients but have, in some cases, harmed or killed patients. It will be interesting to see what Dr. Marin Makary can do to improve FDA’s regulation of drugs. Avorn touches on court cases that have resulted in huge financial settlements by drug manufacturing companies and their stockholders. However, he notes the actual compensation received by individually harmed patients or families is miniscule in respect to the size of the fines; not to mention many billions of dollars the drug companies received before unethical practices were exposed. Avorn notes many FDA’ research and regulation incompetencies allowed drug companies to hoodwink the public about drug companies’ discovered but unrevealed drug side-effects.

A few examples can be easily found in an internet search:

1) Vioxx (Rofecoxib), a pain killer, had to be withdrawn from use in 2004 because it was linked to increased risk of heart attacks and strokes. It was removed from the market in 2004.

2) Fen-Phen (Fenfluramine/Phentermine), a weight-loss drug had to be taken off the market in 1997 because of severe heart and lung complications.

3) Accutane was used to cure acne but was found to be linked to birth defects and had to be withdrawn in 2009.

4) Thalidomide was found to cause birth defects to become repurposed for treatment of certain cancers.

5) A more recent failure of the FDA is their failure to regulate opioids like OxyContin that resulted in huge fines to manufacturers and distributors of the drug.

Lobbyists are hired by drug companies to influence politicians to gain support of drug companies. In aggregate, this chart shows the highest-spending lobbyists in the 3rd Qtr. of 2020 were in the medical industry.

Dr. Avorn argues Big Pharma’s lobbying power has unduly influenced FDA to approve drugs that are not effective in treating patients for their diagnosed conditions. Avorn infers Big Pharma is more focused on increasing revenue than effectively reviewing drug manufacturer’ supplied studies. Avorn argues the FDA has become too dependent on industry fees that are paid by drug manufacturers asking for expedited drug approvals. Avorn infers the FDA fails to demand more documentation from drug manufacturers on their drug’ research. The author suggests many approved opioids, cancer treatment drugs, and psychedelics have questionable effectiveness or have safety concerns. Misleading or incomplete information is provided by drug companies that makes applications an approval process, not a fully relevant or studied action on the efficacy of new drugs.

Avorn is disappointed in the Trump administrations’ selection of Robert Kennedy as the U.S. Secretary of Health and Human Services because of his lack of qualification.

The unscientific bias of Kennedy and Trump in regard to vaccine effectiveness reinforces the likelihood of increased drug manufacturers’ fees that are just a revenue source for the FDA. Trump will likely reward Kennedy for decreasing the Departments’ overhead by firing research scientists and increasing the revenues they collect from drug manufacturers seeking drug approvals.

Trump sees and uses money as the only measure of value in the world.

It is interesting to note that Avorn is a Harvard professor, a member of one of the most prestigious universities in the world. Harvard is being denied government grants by the Trump administration, allegedly because of Harvard’s DEI policy. One is inclined to believe diversity, equity, and inclusion are ignored by Trump because he is part of the white ruling class in America. Trump chooses to stop American aid to the world to reduce the cost of government. American government’s decisions to starve the world and discriminate against non-whites is a return to the past that will have future consequences for America.

Next, Avorn writes about the high cost of drugs, particularly in the United States. Discoveries are patented in the United States to incentivize innovation, but drug companies are gaming that Constitutional right by slightly modifying drug manufacture when their patent rights are nearing expiration. They renew their patent and control the price of the slightly modified drug that has the same curative qualities. As publicly held corporations, they are obligated to keep prices as high as the market allows. The consequence leaves many families at the mercy of their treatable diseases because they cannot afford the drugs that can help them.

Martin Shkreli, American investor who rose to fame and infamy for using hedge funds to buy drug patents and artificially raise their prices to only increase revenues.

The free market system in America allows an investor to buy a drug patent and arbitrarily raise its price. Avorn suggests this is a correctable problem with fair regulation and a balance between government sponsored funding for drug research in return for public funding. Of course, there are some scientists like Jonas Salk in 1953 who refused to privately patent the polio vaccine because it had such great benefit to the health of the world.

Avorn notes the 1990’s drug costs in the U.S. are out of control.

Only the rich are able to pay for newer drugs that cost hundreds of thousands of dollars per year. Americans spend over $13,000 per year per person while Europe is around $5,000 and low-income countries under $500 per year. These expenditures are to extend life which one would think make Americans live longest. Interestingly, America is not even in the top 10. Hong Kong’s average life expectancy is 85.77 years, Japan 85. South Korea 84.53. The U.S. average life expectancy is 79.4. To a cynic like me, one might say what’s 5 or 6 more years of life really worth? On the other hand, billionaires and millionaires like Peter Thiel and Bryan Johnson have invested millions into anti-aging research.

Avorn reinforces the substance of Michael Pollan’s book “How to Change Your Mind” which reenvisions the value of hallucinogens in this century.

Avorn notes hallucinogens efficacy is reborn in the 21st century to a level of medical and social acceptance. Avorn is a trained physician as opposed to Pollan who is a graduate with an M.A. in English, not with degrees in science or medicine.

In reviewing Avorn’s informative history, it is apparent that patients should be asking their doctors more questions about the drugs they are taking.

Drugs have side effects that can conflict with other drugs being taken. In this age of modern medicine, there are many drugs that can be effective, but they can also be deadly. Drug manufacturers looking at drug creation as only revenue producers is a bad choice for society.

Avorn’s history of the drug industry shows failure in American medicines is more than the mistake of placing an incompetent in charge of the U.S.

Taking money away from research facilities diminishes American innovation in medicine and other important sciences. However, research is only as good as the accuracy of its proof of efficacy for the treatment of disease and the Hippocratic Oath of “First, do no harm”. A government designed to use public funds to pick winners and losers in the drug industry threatens human health. Only with the truth of science discoveries and honest reporting of drug efficacy can a physician offer hope for human recovery from curable diseases.

PROJECT 2025

Only the Constitution of the United States stands between Trump’s authoritarianism and what has made America one of the wealthiest countries in the world.

Books of Interest
 Website: chetyarbrough.blog

The Project (How Project 2025 Is Reshaping America)

By: David A. Graham

Narrated By: Ari Fliakos

David A. Graham (Author, journalist, staff writer at The Atlantic.)

Graham has taken the time to dissect the policies proposed by the Heritage Foundation’s support and creation of Project 2025. Project 2025 is a political treatise that seems to outline many of the policies and objectives of the Trump administration.

As Graham notes, even though Trump is unlikely to have read Project 2025, its content seems to outline much of what Trump has done or is trying to do in his Presidency.

A priority in Project 2025 is downsizing the federal government. Interestingly, government employee firings began as soon as Trump entered the oval office. With Trump’s appointment of Elon Musk as the leader of DOGE (the Department of Government Efficiency) over 200,000 federal workers have been discharged. An estimated 10,000 employees were discharged from the Department of Health and Human Services. If all of these firings were to be permanent, an estimated $1.17 billion to $1.26 billion would be saved per year. With 2 million federal employees, less than 1 percent of the payroll cost of government has been SAVED.

Three things come to mind with the 1 percent cost reduction in government employee payroll.

One, is the effect of a job lost to a family who depends on gainful employment. Two, what public services are lost as a result of 2oo,000 fired government employees. And finally, what value is there to the public in reducing government payroll cost by less than 1 percent?

Of course, some will say that misses the point of the symbolic value of reducing the cost of government.

After all, America is founded on capitalism not socialist welfare. Yes and no. Yes, we are capitalists. No, we benefit from government employees who are gainfully employed because they buy things with the money they make while providing service to the public. Is the risk of unemployment in America worth the cost of some human inefficiency?

Project 2025 recommends tax system overhaul with the implementation of a flat income tax.

Trump has reduced jobs in the Department of the IRS. One should remind oneself that the present tax system takes the same maximum amount of money per year out of a family’s income for social security whether they make a million dollars per year or minimum wage. The social security tax rate is 6.2% of up to $176,100 of income per year. After one who is making more than $176,100, no further social security tax is taken. Americans pay that 6.2% whether they make minimum wage or millions of dollars per year. There is something wrong with that picture. Tax reform is needed in America, but the tax reform Trump is interested in is for rich capitalists, not minimum wage earners.

Trump wants to abolish the IRS and finance the government with tariffs and a sales tax.

He wants to have a national sales tax of 23% or roughly 30 cents per dollar spent. That tax will be a burden to the poor but nothing to the rich. Trump perceives an equal benefit to minimum wage workers because they would not have to pay taxes on tips, overtime, and social security. Is that tax benefit equal to corporate tax reductions of 21% to 20% and a reduced rate of 15% for U.S. manufacturers. More jobs may or may not be created, but who gains the most benefit?

Trump infers corporation owners and managers would not put tax savings in their pockets but would create more jobs.

Two entitlement programs Trump believes will be unnecessary as a result of his tax changes are Medicare and Medicaid. Trump supporters believe economic growth will offset the negative impact that his tax reform plan will have on the poor. Does that make it unnecessary to have Medicare or Medicaid for the poor?

Trump is making a mockery of the Constitution by indiscriminately arresting and deporting anyone who cannot prove their status as a legal resident of America.

Project 2025 insists on immigration enforcement with improved border security and tighter immigration policies. Trump endorses that plan, but it is a job for Congress, not an autocratic President. He is willing to pay immigrants with American tax dollars for them to return to their countries of birth. Whose money is it that Trump is choosing to use?

Trump believes global warming is just a seasonal event in the history of earth.

Project 2025 recommends rolling back environmental regulations and endorsing fossil fuels over renewable energy. Trump endorses that plan by rolling back environmental regulations because he believes global warming is a fiction. Science is a fiction to President Trump.

Project 2025 recommends strengthening the executive branch of government and decreasing the rolls of Congress and the courts.

Project 2025 recommends strengthening the executive branch of government and decreasing the rolls of Congress and the courts that are the basis upon which separation of powers were written into the Constitution. Trump is ignoring fundamental tenants of the Constitution like Due Process of Law in the deportation of immigrants.

Project 2025 recommends criminalizing pornography, removing legal protections for anti-LGBT discrimination, and ending diversity programs that drive for equality of all Americans. Trump is using the office of the Presidency to punish elite colleges that have DEI programs meant to address American social inequality.

Trump believes what he believes and acts on those beliefs. His sexual picadilloes are ok but pornography is not. The author shows Trump has support for his beliefs in Project 2025. His support is equally apparent in the free vote of a majority who voted for him in the last election. Only the Constitution of the United States stands between Trump’s authoritarianism and what has made America one of the wealthiest countries in the world.

RISK/REWARD

AI is only a tool of human beings and will be misused by some leaders in the same way Atom bombs, starvation, disease, climate, and other maladies have harmed the sentient world. AI is more of an opportunity than threat to society.

Books of Interest
 Website: chetyarbrough.blog

A Brief History of Artificial Intelligence (What It Is, Where We Are, and Where We Are Going)

By: Michael Wooldridge

Narrated By: Glen McCready

Michael Wooldridge (Author, British professor of Computer Science, Senior Research Fellow at Hertford College University of Oxford.)

Wooldridge served as the President of the International Joint Conference in Artificial Intelligence from 2015-17, and President of the European Association for AI from 2014-16. He received a number of A.I. related service awards in his career.

Alan Turing (1912-1954, Mathematician, computer scientist, cryptanalyst, philosopher, and theoretical biologist.)

Wooldridge’s history of A.I. begins with Alan Turing who has the honorific title of “father of theoretical computer science and artificial intelligence”. Turing is best known for breaking the German Enigma code in WWII with the development of an automatic computing engine. He went on to develop the Turing test that evaluated a machine’s ability to provide answers to questions that exhibited human-like behavior. Sadly, he is equally well known for being a publicly persecuted homosexual who committed suicide in 1954. He was 41 years old at the time of his death.

Wooldridge explains A.I. has had a roller-coaster history of highs and lows with new highs in this century.

Breaking the Enigma code is widely acknowledged as a game changer in WWII. Enigma’s code breaking shortened the war and provided strategic advantage to the Allied powers. However, Wooldridge notes computer utility declined in the 70s and 80s because applications relied on laborious programming rules that introduced biases, ethical concerns, and prediction errors. Expectations of A.I.’s predictability seemed exaggerated.

The idea of a neuronal connection system was thought of in 1943 by Warren McCulloch and Walter L Pitts.

In 1958, Frank Rosenblatt developed “Perception”, a program based on McCulloch and Pitt’s idea that made computers capable of learning. However, this was a cumbersome programming process that failed to give consistent results. After the 80s, machine learning became more usefully predictive with Geoffrey Hinton’s devel0pment of backpropagation, i.e., the use of an algorithm to check on programming errors with corrections that improved A.I. predictions. Hinton went on to develop a neural network in 1986 that worked like the synapse structure of the brain but with much fewer connections. A limited neural network for computers led to a capability for reading text and collating information.

Geoffrey Hinton (the “Godfather of AI” won the 2018 Turing Award.)

Then, in 2006 Hinton developed a Deep Belief Network that led to deep learning with a type of a generative neural network. Neural networks offered more connections that improved computer memory with image recognition, speech processing, and natural language understanding. In the 2000s, Google acquired a deep learning company that could crawl and index the internet. Fact-based decision-making, and the accumulation of data, paved the way for better A.I. utility and predictive capability.

Face recognition capability.

What seems lost in this history is the fact that all of these innovations were created by human cognition and creation.

Many highly educated and inventive people like Elon Musk, Stephen Hawking, Bill Gates, Geoffrey Hinton, and Yuval Harari believe the risks of AI are a threat to humanity. Musk calls AI a big existential threat and compares it to summoning a demon. Hawking felt Ai could evolve beyond human control. Gates expressed concern about job displacement that would have long-term negative consequences with ethical implications that would harm society. Hinton believed AI would outthink humans and pose unforeseen risks. Harari believed AI would manipulate human behavior and reshape global power structures and undermine governments.

All fears about AI have some basis for concern.

However, how good a job has society done throughout history without AI? AI is only a tool of human beings and will be misused by some leaders in the same way atom bombs, starvation, disease, climate, and other maladies have harmed the sentient world. AI is more of an opportunity than threat to society.

FUTURE A.I.

Human nature will not change but A.I. will not destroy humanity but insure its survival and improvement.

Books of Interest
 Website: chetyarbrough.blog

Human Compatible (Artificial Intelligence and the Problem of Control)

By: Stuart Russell

Narrated By: Raphael Corkhill

Stuart Johnathan Russell (British computer scientist, studied physics at Wadham College, Oxford, received first-class honors with a BA in 1982, moved to U.S. and received a PhD in computer science from Stanford.)

Stuart Russell has written an insightful book about A.I. as it currently exists with speculation about its future. Russell in one sense agrees with Marcus’s and Davis’s assessment of today’s A.I. He explains A.I. is presently not intelligent but argues it could be in the future. The only difference between the assessments in Marcus’s and Davis’s “Rebooting AI” and “Human Compatible” is that Russell believes there is a reasonable avenue for A.I. to have real and beneficial intelligence. Marcus and Davis are considerably more skeptical than Russell about A.I. ever having the equivalent of human intelligence.

Russell infers A.I. is at a point where gathered information changes human culture.

Russell argues A.I. information gathering is still too inefficient to give the world safe driverless cars but believes it will happen. There will be a point where fewer deaths on the highway will come from driverless cars than those that are under the control of their drivers. The point is that A.I. will reach a point of information accumulation that will reduce traffic deaths.

A.I. will reach a point of information accumulation that will reduce traffic deaths.

After listening to Russell’s observation, one conceives of something like a pair of glasses on the face of a person being used to gather information. That information could be automatically transferred by improvements in Wi-Fi to a computing device that would collate what a person sees to become a database for individual human thought and action. The glasses will become a window of recallable knowledge to its wearer. A.I. becomes a tool of the human mind which uses real world data to choose what a human brain comprehends from his/her experience in the world. This is not exactly what Russell envisions but the idea is born from a combination of what he argues is the potential of A.I. information accumulation. The human mind remains the seat of thought and action with the help of A.I., not the direction or control by A.I.

Russell’s ideas about A.I. address the concerns that Marcus and Davis have about intelligence remaining in the hands of human’s, not a machine that becomes sentient.

Russell agrees with Marcus, and Davis–that growth of A.I. does have risk. However, Russell goes beyond Marcus and Davis by suggesting the risk is manageable. Risk management is based on understanding human action is based on knowledge organized to achieve objectives. If one’s knowledge is more comprehensive, thought and action is better informed. Objectives can be more precisely and clearly formed. Of course, there remains the danger of bad actors with the advance of A.I., but that has always been the risk of one who has knowledge and power. The minds of a Mao, Hitler, Beria, Stalin, and other dictators and murderers of humankind will still be among us.

The competition and atrocities of humanity will not disappear with A.I. Sadly, A.I. will sharpen the dangers to humanity but with an equal resistance by others that are equally well informed. Humanity has managed to survive with less recallable knowledge so why would humanity be lost with more recallable knowledge? As has been noted many times in former book reviews, A.I. is, and always will be, a tool of human beings, not a controller.

The world will have driverless cars, robotically produced merchandise, and cultures based on A.I.’ service to others in the future.

Knowledge will increase the power and influence of world leaders to do both good and bad in the world. Human nature will not change but A.I. will not destroy humanity. Artificial Intelligence will insure human survival and improvement. History shows humanity has survived famine, pestilence, and war with most cultures better off than when human societies came into existence.

ABSOLUTION

History of the world has shown all forms of government are “equal opportunity” inhibitors, if not destroyers.

Books of Interest
 Website: chetyarbrough.blog

Secondhand Time (The Last of the Soviets)

By: Svetlana Alexievich

Narrated By: Amanda Carlin, Mark Bramhall, Cassandra Campbell & 8 more.

Svetlana Alexievich (Author, Belarusian investigative journalist, winner of the Nobel Prize in Literature in 2015.)

Svetlana Alexievich’s “Secondhand Time” is a remarkable and informative explanation of why Putin believes he is right and why many citizens of Russia seem to continue in their support of his administration.

Map of the former U.S.S.R.

Alexievich conducts a series of interviews with Russian citizens of different generations about the U.S.S.R. and its return to the world stage as a Russian nation. The narrators of her book recite those interviews to give listener/readers a complex and enlightening picture of Russian culture. The clash of communist and capitalist ideals is at the foundation of the interviews and the narrators dramatically told stories.

The Russian Soviet Army is the first to arrive in the Battle of Berlin on April 16, 1945. Their flag was hoisted on May 1, 1945.

The citizens of Russia are justifiably proud of their role in WWII that turned the tide of Germany’s war of aggression. (Of course, that is putting aside Stalin’s Machiavellian decision to join Hitler at the beginning of the war.) Some Russian soldiers who fought in that war were disgusted with what they feel was a betrayal by Mikhail Gorbachev of communist ideals for which they lived and died for in the 20th century.

The rejection of communist ideals for capitalism is viewed by some Russians as a tyranny of greed that lays waste to the poor and creates a class of haves and have-nots.

Some Russian veterans of WWII see the seduction of capitalism destroying the ideal of a classless society. Some citizens see the ideal of a government is to demand the wealth of life be spread equally according to individual need. To these believers, enforcement of communist ideals would eliminate private property and greed that would create a classless society. Some believed Stalin exemplified leadership that would achieve that ideal. The hardship of life during Stalin’s rule is considered by some as justified means for the achievement of the Marxist ideal of communism.

Statue of the “Circle of Life” in Norway.

Cultures may be different, but all human life is the same.

The underlying point of these interviews is to show Russian culture is not monolithic, just as culture is not in any nation. All cultures are filled with diversity. There is no singular cultural mind but a range of interests among many factions that establish a nation’s culture. The evidence of that is the contrast of Gorbachev and Putin in Russia and FDR and Trump in America. All four leaders led their countries but represent completely different cultural beliefs.

Alexievich shows there are veterans in Russia who strongly believe Gorbachev was a traitor to his country.

Conservatives, New York Governor Al Smith, Southern Democrats, and isolationists like Charles Beard opposed FDR in America. Putin and Trump have their cultural supporters in today’s national governments, but they also have their critics. The difference is that in Putin’s world, being killed or put in prison for opposition is culturally acceptable. In America, one is reminded of Trump’s deportation and imprisonment of migrants without due process.

The author’s interviews are not suggesting that either Russia or the West have good or bad governments but that every culture tests their leaders.

Many Russians, undoubtedly blame American Democracy for the dismantling of the U.S.S.R. Alexievich interviews Russians who believe the hardship that countries within the U.S.S.R. experienced were not the fault of Stalinist policies but the failure of citizens to live up to the ideals of communism. To anyone who has traveled to the Baltics, that opinion is founded on ignorance of the hostility expressed by citizens of the Baltics who were starved, displaced, jailed, and murdered during their occupation by Russia.

The other part of the story is the rise of the oligarchs in Russia as a result of the greed associated with capitalism.

The gap between rich and poor is accelerated in Russia just as it has been in America. Democracy does not have clean hands when it comes to equality of opportunity. Like the Jewish pogroms in Russia, America’s enslavement, murder, and discrimination of Blacks is proven history.

Siberian Exile during Stalin’s reign in Russia.

Alexievich draws from all sides of Russian beliefs. Those interviewed note the terrible conditions of those exiled to Siberia. Many Russians became disillusioned by the redistribution of wealth and privilege after Gorbachev and Yeltsin showed themselves to not be up to the task of leadership change. In fairness, one wonders who could have been up to the task when Russia had a long history of monarchal and tyrannical leadership?

Alexievich reveals a split between those Russians who want a fairer communist’ socialism or fairer western capitalism. One doubts either is possible with Putin.

A few Russians became immensely wealthy while the majority were somewhat better off but some struggled with the loss of State benefits and fewer jobs. The rising gap between rich and poor soured communist idealists. Even those who had been sent to Siberia by Stalin who toiled and suffered the experience of isolation, slave labor, and frigid weather felt they were no better off because of the loss of a socialist future.

The frightening truth of Alexievich’s book about the culture of Russia is that Putin may be absolved for his atrocities just as leaders of America have been absolved for their mistakes. History of the world has shown all forms of government are “equal opportunity” inhibitors, if not destroyers.

CHOICE

A listener/reader comes away from Pollan’s book with a feeling that there is as much at risk as reward in experimenting with hallucinogens without the aid of professionals. A bad trip can kill you.

Books of Interest
 Website: chetyarbrough.blog

How to Change Your Mind (What the New Science of Psychedelics Teaches Us About Consciousness, Dying, Addiction, Depression, and Transcendence)

By: Michael Pollan

Narrated By: Michael Pollan

Michael Pollan (Author, journalist, professor and lecturer at Harvard and UC Berkeley, received a B.A. in English from Bennington College and M.A. in English from Columbia University.)

“How to Change Your Mind” is a slippery slope examination of hallucinatory drugs. The slipperiness comes from a concern about drug use even though hallucinatory drugs are not addictive. Written by a liberal art’s graduate rather than a physician, psychiatrist, or scientist makes one skeptical of the author’s review and perspective on LSD and other hallucinatory drugs. However, his story is interesting and has an appeal to anyone who has experimented with hallucinogens.

RISKS AND EFFECTS OF HALLUCINOGENS

Pollan’s subject is partly about mushroom drug derivatives, like psilocybin and psilocin, that have hallucinogenic effects. But he also reviews the history of LSD which is a semi-synthetic compound accidentally discovered by a chemist named Albert Hofmann in 1938. LSD is derived from ergot, a type of fungus that grows on rye and other grains.

Albert Hofmann (1906-2008, chemist who synthesized, ingested and studied the effects of LSD.)

Pollan recalls the history of hallucinogenic drugs that evolved from ancient native rituals to public experimentation. Today, medical analysis and treatment with hallucinogenic drugs is being recommended. The revised belief of hallucinogens as a scourge of society is reborn to a level of medical and social acceptance.

One who has lived a long life in the 20th and now 21st century recalls Pollan’s rollercoaster history. Pollan falls on the side of acceptance of the hallucinogenic experience as an aid to society. His reported revisionist belief begins at the age of 60 when he tries a hallucinogenic drug and begins a study of its history. One is somewhat skeptical of Pollan’s objectivity because he is in the business of making a living from writing.

Pollan features several experts in the field of psychedelic research. He refers to Roland Griffiths (upper left corner) now deceased, neuroscientist at Johns Hopkins University who conducted studies on psilocybin’s effect on consciousness and mental health. He meets with Paul Stamets (lower left corner), a mycologist who is a fungi guru who explains where psilocybin mushrooms can be found, how they can be identified, while selling hallucinatory mushrooms to become a wealthy entrepreneur. He writes about James Fadiman (right), a psychologist and researcher who conducted hallucinogenic microdosing experiments on patients to show their potential benefits.

Pollan’s history persuasively argues the benefits of hallucinogenic drugs. However, a bad trip can kill you. On the other hand, Pollan notes recent research shows hallucinogenic drugs have alleviated anxiety, depression, PTSD, addiction, and the fear of dying. He notes psychedelics disrupt the brain’s default modes that negatively affect human behavior.

A listener/reader comes away from Pollan’s book with a feeling that there is as much at risk as reward in experimenting with hallucinogens without the aid of professionals.

THINKING

A.I. will continue to grow as an immense gatherer of information. Will it ever think? Can, should, or will future prediction and political policy be based only on knowledge of the past?

Books of Interest
 Website: chetyarbrough.blog

Rebooting AI (Building Artificial Intelligence We Can Trust)

By: Gary Marcus and Ernest Davis

Narrated By: Kaleo Griffith

Gary Marcus (American psychologist, neuroscience & AI researcher)
Ernest Davis (Professor of Computer Science @ Courant Institute of Mathematical Sciences NYU.)

These two academics explain much of the public’s misunderstanding of the current benefit and threat of Artificial Intelligence.

Marcus and Davis note that A.I. cannot read and does not think but only repeats what it is programmed to report.

They are not suggesting A.I. is useless but that its present capabilities are much more limited than what the public believes. In terms of product search and economic benefit to retailers, A.I. is a gold mine. But A.I.’s ability to safely move human beings in self-driving cars, free humanity from manual labor, or predict cures for the diseases of humanity are far into the future. A.I. is only a just-born baby.

Self-driving cars, robot servants, and cures for medical maladies remain works in process for Artificial Intelligence.

Marcus and Davis note A.I. usefulness remains fully dependent on human reasoning. It is a tool for recall of documented information and repetitive work. A.I. is not sentient or capable of reasoning based on the information in its memory. Because of a lack of reasoning capability, answers to questions are based on whatever information has been fed to an A.I. entity. It does not use reason to answer inquiry but only recites responses to questions from programmed information in its memory. If sources of programmed information are in conflict, the answers one receives from A.I. may be right, wrong, conflicted, or unresponsive. You can as easily get an answer from A.I. that is wrong as one that is right because it is only repeating what it has gathered from the past.

What Marcus and Davis show is how important it is that questions asked of Microsoft’s Copilot, ChatGPT, Watson, or some other A.I. platform be phrased carefully.

The value of A.I. is that it can help one recall pertinent information only if questions are precisely worded. This is a valuable supplement to human memory, but it is not a reasoned or infallible resource.

Marcus and Davis explain “Deep Learning” is not a substitute for human reasoning, but it is a supplement for more precise recorded information.

Even with multilayered neural networks, like deep learning which attempt to mimic human reasoning by patterning of raw data, can be wrong or confused. One is reminded of the Socratic belief of “I know something that I know nothing.” Truth is always hidden within a search for meaning, i.e., a gathering of information

The true potential of A.I. is in its continued consumption of all sources of information to respond to queries based on a comprehensive base of information. The idea of an A.I. that can read, hear, and collate all the information in the world is at once frightening and thrilling.

The risk is the loss of human freedom. The reward is the power of understanding. However, the authors explain there are many complications for A.I. to usefully capitalize on all the information in the world. Information has to be understood in the context of its contradictions, its ethical consequence, information bias, and the inherent unpredictability of human behavior. Even with knowledge of all information in the world, decisions based on A.I. do not ensure the future of humanity? Should humanity trust A.I. to recommend what is in the best interest of humanity based on past knowledge?

Markus and Davis argue A.I. is not, does not, and will not think.

A.I. will continue to grow as an immense gatherer of information. Will it ever think? Can, should, or will future prediction and political policy be based only on knowledge of the past?

HEALTH

“This is Your Brain on Parasites” is a bad book title but McAuliffe has written an interesting book about physical and mental health, and the treatments being researched in the 21st century.

Books of Interest
 Website: chetyarbrough.blog

This is Your Brain on Parasites (How Tiny Creatures Manipulate Our Behavior) and Shape Society

By: Kathleen McAuliffe

Narrated By: Nicol Zanzarella

Kathleen McAuliffe (Author, science journalist who has published in The New York Times, The Atlantic, and Smithsonian. Received an M.A. in natural science from Trinty College Dublin.)

Kathleen McAuliffe apprises the public of the importance of personal health along with a somewhat bizarrely titled book “This is Your Brain on Parasites”. McAuliffe’s book is about the science of health and its maintenance. The idea of a parasite in one’s brain seems unworthy of a book because of the creepy implication of possession. However, McAuliffe refers to a physician and several research scientists that have found evidence of brain parasites that effect animal and human behavior.

Dr. Robert Sapolsky. (Now retired but has written several books on biology and animal behavior.)

Dr. Robert Sapolsky, a neuroscientist and professor at Stanford studied what is called a Toxoplasma gondii parasite. It forms cysts in brain tissue that are shown to affect human behavior. People who have developed the cysts have shown symptoms of risk-taking behavior, and mental dysfunction like schizophrenia.

Dr. Jaroslav Flegr is a parasitologist, evolutionary biologist and professor of biology at the Faculty of Science, and professor at Charles University in Prague.

McAuliffe meets with a Czech scientist, Dr. Jaroslav Flegr, who conducted research showing the Toxoplasma gondii parasite in cat feces can infect the brain of a human being. The author meets other American research scientists that show how parasites infect animal brains whose behavior is affected in ways that are not natural to their species. A parasite being the source of a diseased brain has implications for treating mentally dysfunctional patients that may have a parasitic infection.

What McAuliffe’s book implies is the importance of washing one’s hands when handling pets, or their fecal material.

“This is Your Brain…” reminds one of the importance of hygiene when replenishing a bird feeder or filling an animal feeding trough to avoid possible parasites.

As most know, Kennedy is not a believer in vaccination despite a growing measles epidemic and the proof that vaccination works. McAuliffe does believe there are circumstances where a child crawling across the floor of a clean house gathers some immunity naturally but that un-common pathogens require uncommon vaccination.

Two other subjects mentioned by McAuliffe is natural and science made vaccinations and the benefits they provide humanity. This is a particularly timely suggestion considering Trump’s appointment of Robert F. Kennedy Jr. (a confessed anti-vaxxer) as the Secretary of Health and Human Services.

McAuliffe notes how research is showing how certain microbes can remove calories from food and how certain drugs can reduce hunger among overweight patients. She reflects on the intersection of microbiology and human health.

Another interesting examination by McAuliffe is the science research being done on gut microbiomes, a community of microorganisms in human digestive systems.

The research on microbiomes has resulted in effective weight loss drugs that have become popular medications for people struggling with weight gain.

“This is Your Brain on Parasites” is a bad book title but McAuliffe has written an interesting book about physical and mental health, and the treatments being researched in the 21st century.

HUMAN HOPE

Migration is the movement of people to new areas of the world for work, better living conditions, and safety. In that process the world economy is strengthened. .

Books of Interest
 Website: chetyarbrough.blog

The Shortest History of Migration

By: Ian Goldin

Narrated By: Julian Elfer

Ian Andrew Goldin (South African born professor at the University of Oxford, specializes in globalization and development.)

Professor Goldin has written a history of migration that reminds one of the well-known phrases attributed to Socrates: “I know that I know nothing”. Goldin is born in South Africa to a Lithuanian father who fled his home country to escape political and social upheaval in Europe during the early 20th century. In retrospect, that migration saved the future of the Goldin’s from Stalinist suppression after WWII. It is ironic that Ian Goldin is raised in South Africa where white suppression of native South Africans was common. “The Shortest History of Migration” is no apologia, but it is a forthright history of the ubiquity of world migration.

Migration is an essential characteristic of civilization believed to have begun in Africa.

The obvious irony of human origin is the darker skin tone of our first ancestors who had higher levels of skin melanin to protect them from the harsh effects of the sun. Humanity began as a species of a black ancestor, an estimated 6 to 7 million years ago.

Neanderthal precursor of human beings.

Goldin implies humans moved from Africa to explore the world. They may have left to escape the harshness of their existence or because of the nature of species’ curiosity. Their change in environment led to changes in their physiognomy (facial features and expressions) caused by the evolutionary nature of life and the exigencies of environment. The point is that migration has been a part of history since the beginning of life on earth.

What may be forgotten by some is that migration was largely unregulated until WWI according to Goldin.

That seems largely true except the United States passed the Naturalization Act of 1790 that established rules for citizenship and an Immigration Act of 1891 that created the U.S. Bureau of Immigration; both of which implied regulation. Nevertheless, the fundamental point is that migration has been a part of society from the beginning of human life.

WWI generated many new laws and policies about migration.

Wartime measures required passports and border crossing cards to manage migration. National security increased scrutiny of immigrants. Broader societal and political concerns about migration spread across the world. Migration became more complicated.

Goldin argues the benefit of migration is misunderstood and misrepresented by leaders like Donald Trump.

Goldin suggests the economic impact of Trump’s anti-migrant beliefs and policies will undermine both the world and American economies. In 2023, an estimated 18% of the economic output of the American economy came from migration. The two industries most impacted are agriculture and construction but many immigrants work in caregiving and medical professions, all of which will be impacted by labor shortages. Goldin notes that migrants working in other countries send money back to their home countries that amount to more revenue than is provided by tourism and foreign aid. Many, if not most, economists would argue migration is a cornerstone of economic growth and stability. Trump’s false statements about migrant criminality are overblown and unsupported by economic statistics that show migrants contributed an estimated $25.7 billion in 2022 to the Social Security system in taxes that benefit aged American citizens (like myself).

Trump policies will not return American to the manufacturing prosperity of the twentieth century but to a possible depression like that of the 1930s or, at the very least, a recession like that of 2007-2009.

Migration is the movement of people to new areas of the world for work, better living conditions, and safety. In that process the world economy is strengthened.

HUMAN

What is the value of high IQ? If everyone was smarter, would they be happier? It seems the only real value of genetics is in the prevention of known diseases, not in improvement of IQs or creation of a perfect human being (whatever that is).

Books of Interest
 Website: chetyarbrough.blog

The Social Genome: The New Science of Nature and Nurture

By: Dalton Conley

Narrated By: Christopher Douyard

Dalton Clark Conley (Author, Princeton University professor, American sociologist.)

Dalton Conley offers a complex explanation of why one child intellectually and financially excels while others are left behind. The “Social Genome” is an attempt to explain the complexity and inadequacy of genetic research. Not too surprisingly, there seems a correlation between wealth and intellectual development, but its relationship includes familial and environmental nurturing in ways that are too complex for today’s science to measure.

FAMOUS WOMEN IN HISTORY (Many women are as intellectually strong and mentally tough as men, e.g.  Cleopatra, Sojourner Truth, Indira Gandhi, Golda Meir, Benazir Bhutto, Malala Yousafzai, and others.)

Dalton argues both genetics and environment shape human intellect and economic success. However, science’s current knowledge of genetic and environmental impact is not clearly understood in a way to aid human development. The current limitations of science make it impossible to determine the precise genetic and environmental factors that shape human development. Dalton offers many examples of how genetics and environment are relevant to human development, but neither are precisely measurable nor manageable.

The idea of clearly understanding the genetic and environmental causes of who humans become is a bit frightening.

Even if it were possible to achieve precise measurement of genetic and environmental influences, should that knowledge be used to create designer human beings?

Piketty argues that the income gap widens after World War II.  He estimates 60% of 2010’s wealth is held by less than 1% of the population. 

Dalton does believe there is a correlation between economic well-being and IQ, but the correlation is affected by genetic inheritance. Dalton concludes economic well-being is a positive factor in IQ improvement. That raises questions about how one can improve the economic well-being of a society to improve IQ. Dalton infers there is no one size fits all solution for IQ improvement. Nurture and nature are too intimately intertwined to know how IQ of a society can be improved. A conclusion one may draw is that environmental and societal factors like human nutrition, general education and improved equal opportunity can mitigate IQ diminishment. Whether one should modify human genomes is a step too far.

In many ways, this is a frustrating book to listen to or read.

If all people looked more alike than different would there be less conflict in the world? No, but being of one race or another makes a difference in one’s opportunities in the world. What is the value of high IQ? If everyone was smarter, would they be happier? It seems the only real value of genetics is in the prevention of known diseases, not in improvement of IQs or creation of a perfect human being (whatever that is).