REVIEWS AND VIEWS OF LIFE

AGI

Books of Interest
Website: chetyarbrough.blog

How to Think About AI (A Guide for the Perplexed)

By: Richard Susskind

Narrated By: Richard Susskind

Richard Susskind (Author, British IT adviser to law firms and governments, earned an LL.B degree in Law from the University of Glasgow in 1983, and has a PhD. in philosophy from Columbia University.)

Richard Susskind is another historian of Artificial Intelligence. He extends the history of AI to what is called AGI. He has an opinion about the next generation of AI called Artificial General Intelligence. AGI (Artificial General Intelligence) is a future discipline suggesting AI will continue to evolve to perform any intellectual task that a human can.

These men were the foundation of what became Artificial Intelligence. AI was officially founded in 1956 at a Dartmouth Conference attended by John McCarthy, Marvin Minsky, Nathaniel Rochester, and Claude Shannon. Conceptually, AI came from Alan Turing’s work before and during WWII when he created the Turing machine that cracked the German secret code.

McCarthy and Minsky were computer and cognitive scientists, Rochester was an engineer and became an architect for IBM’s first computer, Shannon (an engineer) and Turing were both mathematicians with an interest in cryptography and its application to code breaking.

Ada Lovelace (English Mathematician 1815-1852)

Though not mentioned by Susskind, two women, Ada Lovelace and Grace Hopper played roles in early computer creation (Lovelace as an algorithm creator for Charles Babbage in the 19th century, and Hopper as a computer scientist that translated human-readable code into machine language for the Navy).

Susskind’s history takes listener/readers to the next generation of AI with Artificial General Intelligence (AGI).

Susskind recounts the history of AI’s ups and downs. As noted in earlier book reviews, AI’s potential became known during WWII but went into hibernation after the war. Early computers lacked processing capability to support complex AI models. The American federal government cut back on computer research for a time because of unrealistic expectations that seemed unachievable because of processing limitations. AI research failed to deliver practical applications.

The invention of transistors in the late 1940’s and 50s and microprocessors in the 1970s reinvigorated AI.

Transistor and microprocessor inventions addressed the processing limitations of earlier computers. John Bardeen, Walter Brattain, and William Shockley working for Bell Laboratories were instrumental in the invention of transistors and microprocessors. Their inventions replaced bulky vacuum tubes and miniaturized more efficient electronic devices. In the 1970s Marcian “Ted” Hoff, Federico Faggin, and Stanley Mazor, who worked for Intel, integrated computing functions onto single chips that revolutionized computing. The world rediscovered the potential of AI with these improvements in power. McCarthy and Minsky refine AI concepts and methodologies.

Geoffrey Hinton (British Canadian computer scientist.)

With the help of others like Geoffrey Hinton and Yann LeCun, the foundation for modern AI is reinvigorated with deep learning, image recognition, and processing that improves probabilistic reasoning. Human decision-making is accelerated in AI. Susskind suggests a blurred line is created between human and machine control of the future with the creation of Artificial General Intelligence (AGI).

With AGI, there is the potential for loss of human control of the future.

Societal goals may be unduly influenced by machine learning that creates unsafe objectives for humanity. The pace of change in society would accelerate with AGI which may not allow time for human regulation or adaptation. AGI may accumulate biases drawn from observations of life and history that conflict with fundamental human values. If AGI grows to become a conscious entity, whatever “conscious” is, it presumably could become primarily interested in its own existence which may conflict with human survival.

Like history’s growth of agricultural development, religion, humanist enlightenment, the industrial revolution, and technology, AGI has become an unstoppable cultural force.

Susskind argues for regulation of AGI. Is Artificial General Intelligence any different than other world changing cultural forces? Yes and no. It is different because AGI has wider implications. AGI reshapes or may replace human intelligence. One possible solution noted by Ray Kurzweil is the melding of AI and human intelligence to make survival a common goal. Kurzweil suggests humans should go with the flow of AGI, just like it did with agriculture, religion, humanism, and industrialization.

Susskind suggests restricting AGI’s ability to act autonomously with shut-off mechanisms or accessibility restrictions on human cultural customs. He also suggests programming AGI to have ethical constraints that align with human values and a rule of “do no harm”, like the Hippocratic oath of doctors for their patients.

In the last chapters of Susskind’s book, several theories of human existence are identified. Maybe the world and the human experience of it are only creations of the mind, not nature’s reality. What we see, feel, touch, and do are in a “Matrix” of ones and zeros and that AGI is just what humans think they see, not what it is. Susskind speculates on the growth of virtual reality developed by technology companies becoming human’s only reality.

All this critic has read and tried to understand suggests AI and AGI will always only be a tool of humanity’s imperfect existence.

AI and AGI are threats to humanity, but the threat is in the hands of human beings. As the difference between virtual reality and what is real becomes more unclear, it will be used by human beings who could accidentally, or with prejudice or craziness, destroy humanity. The same might be said of nuclear war which is also in the hands of human beings. A.I. and A.G.I. are not the threat. Conscious human beings are the threat.

Humans will learn to use and adapt to Artificial General Intelligence in the same way it has adapted to belief in a Supreme Being, the Age of Reason, the industrial revolution, and other cultural upheavals. However, if science gives consciousness (whatever that is) to A.I., all bets are off. The end of humanity may be in that beginning.

INTELLIGENCE

After two or three chapters of Huston’s book, reader/listeners will likely complete it. The difficulty, as with all good advice, is following it.

Books of Interest
Website: chetyarbrough.blog

SHARP (Simple Ways to Improve Your Life with Brain Science)

By: Therese Huston PhD

Narrated By: Theresa Bakken

Therese Huston (Author, earned an MS and PhD in Cognitive Psychology from Carnegie Mellon University.)

Therese Huston is a well-known public speaker who has written a book that has appeal for those who wish to know what they can do to improve their memory and cognitive abilities. This is not a book some will be interested in either listening to or reading. Many presume they have a proscribed intelligence and memory largely determined by genetic inheritance. Huston infers there is some science-based truth in that opinion but that one’s memory, cognitive ability, and psychological health can be treated, if not improved, at any age.

Huston’s prescription for improved memory and cognitive ability requires effort.

Undoubtedly, we inherit much of our innate cognitive ability but whatever one’s genetic inheritance and age may be Huston argues cognition and memory can be improved. Huston discusses areas of the brain that are the base from which cognition and memory originate, are stored, and then called upon.

Huston notes the hippocampus, amygdala, prefrontal cortex, neocortex, cerebellum, and basal ganglia are key brain areas involved in cognition and memory.

The hippocampus is the primary location of memories, but the other five areas interact with one’s personal experiences in ways ranging from emotion, individual understanding, decision-making, reasoning, skill development, and formed habits. As we age, the way we process, store, and retrieve information deteriorates. We lose some memories, process information more slowly, and find it more difficult to process new information in the context of past experience.

What Huston explains is that exercise, visual, and tactical experience can improve memory and cognition at every age.

Staying active, experiencing the world in ways that stimulate the production of dopamine, and exercising effort to learn and do new things improves cognitive ability and memory. Dopamine is a neurotransmitter in the human body that regulates mood, focus and behavior. It is released by the body when it is stimulated by exercise, engaging experience, and learning new things. Huston offers advice on how one at any age can improve their mental health and care for themselves and others when they are troubled by various common and extraordinary events in life. Life’s events stimulate the release of dopamine which can illicit rage and bad behavior but also provide focus and beneficial behavior.

Huston suggests 14 generally simple ways of helping oneself and others cope with the stresses of life.

Many of her solutions are commonly understood, others less so. Not surprisingly, she notes exercise, proper nutrition, quality sleep, and deep breathing are important for maintenance and improvement of brain function and memory. Some more difficult and less understood aids to brain health and memory are 1) importance of social engagement, 2) learning new things from personal and other’s recorded experience, and 3) practicing ways of reducing the stresses of life in yourself and others you care about.

One who reads or listens to “Sharp” will recognize the value of Huston’s advice for improving memory and cognitive ability.

After two or three chapters, reader/listeners will likely complete her book. The difficulty, as with all good advice, is following it.

RIGHT & WRONG

The story of “…Belle Lettres…” inelegantly reminds one of the effects of Trump on America’s reputation.

Books of Interest
Website: chetyarbrough.blog

The Belles Lettres Papers (A Novel)

By: Charles Simmons

Narrated By: Alex Hyde-White

Charles Paul Simmons (1924-2017, Author and former American editor for The New York Times Book Review, graduate of Columbia University in 1948.)

“The Belles Lettres Papers” is a fictional account about the destruction of an American book review company. Written by a person who worked as the editor for the NY Times Book Review gives credibility to its author. One wonders how the nationally famous paper felt about his book. Simmons writes a story of a magazine company that exclusively reviews new books that become literary successes, sometimes bestsellers, or dead or dying dust gatherers.

To this book critic, Simmons certainly seems to know what he is writing about but “The Belles Lettres Papers” falls into a dust gatherer category of books.

Book reading or listening is an educational, sometimes entertaining, experience. There are so many books written that it is impossible to know what to read or listen to without someone’s review of what has been newly or recently published. Of course, there are genres that a reader/listener will choose that influences their book choices. Even when one limits themselves to a genre, there are too many choices that require a way of limiting one’s choice.

Experience reveals “best seller” is not a consistently reliable way of choosing a book, but it is one of the most commonly used methods of selection.

What “…Belles Lettres…” reveals is the potential corruption that can inflate a books placement on a best seller list. Book review publications, like all business enterprises, have owners and employees that have various levels of honesty, capability, and ethical standards. What Simmons shows is how every business owner and employee is subject to the influence of money and power.

The potential weaknesses of humanity play out in every organization that provides service or material to the public.

Simmons shows how a fictional book review company has employees who are corrupted by the power of their positions and the money they make. The fictional company has a male business manager who thinks his female secretary wishes to have sex with him because of natural attraction. Ethically, no employee reporting to a manager they work for should have sexual relations with a direct report. This is particularly egregious in Simmon’s story because of sexual inequality that permeates society. As Lord Acton’s observation about power (power corrupts, absolute power corrupts absolutely), a person who has power over another is always at risk of self-delusion.

Simmons goes on to explain how undercompensating employees can corrupt an organization by incentivizing theft and other ways of undermining a company’s integrity.

Simmons addresses the incentive of owners or those in power of an organization to cut personnel employment to save money at the cost of product quality or service. America is experiencing that today with the actions of the Trump Administration in arbitrarily firing federal employees, regardless of what they do for American citizens.

In a last chapter, Simmons addresses the revisions that can occur in a company that decides on a wholesale turnover in employees.

The integrity of a company’s mission can be sorely challenged. In the case of “…Belle Lettres…” a decision for publication of salacious books replaces the company’s former studied reviews of good writers. The organization loses its reputation as a reviewer of high-quality publications.

Trump’s assessment of immigration.

The story of “…Belle Lettres…” inelegantly reminds one of the effects of Trump on America’s reputation as a supporter of western society by reducing foreign aid, undermining university independence, denying global warming, arbitrarily firing government employees, and expelling American immigrants.

ARROGANCE

A President who only sees government as a cost and the wealthy as the nation’s only benefactors, compounds America’s inability to solve the problems of poverty with eviction being a preeminent symptom.

Books of Interest
Website: chetyarbrough.blog

Evicted (Poverty and Profit in the American City)

By: Matthew Desmond

Narrated By: Dion Graham

Matthew Desmond (Author, sociologist and a Pulitzer Prize winner, Professor of Sociology at Princeton.)

Matthew Desmond has written about American poverty in “Evicted”. There are two types of poverty. One is a worker who is not making enough money to be anything more than poor. The second kind of poor is grinding poverty where one must choose between having food to eat or a roof over one’s head. One who is poor can live in America, may get an education, find a job, and get along in life. However, those with too little money to eat and have shelter–live lives of desperation. Desmond’s book is about the latter to show how American society is failing desperate citizens. Desmond interviews several poor Americans that offer a clear understanding of the difference between being poor in America and being desperately poor in America.

Some argue America is the land of opportunity and if one cannot grasp opportunity, it is because they create their own problems.

“Land of opportunity” believers argue there are jobs in America and those who choose to beg for food rather than work deserve their fate. The truth is that many jobs in America do not pay enough for those who have jobs to pay rent and feed their families. Housing is expensive and affordable housing is not being produced in large enough quantities to reduce the costs of housing. Affordable housing is hard to build because many homeowners resist having it built in their neighborhoods. When land is found, it is often too expensive for the builder to make a profit with low rents. The cost of construction is often higher than it needs to be because of high land prices, building code requirements, or rezoning needed to allow multifamily housing.

Education in America is not meeting the needs of its citizens.

School availability is not well enough managed to ensure education for all who live in America. Sex education and contraception are being discouraged in school, which is a foolish, self-destructive societal mistake. Healthcare is too expensive for many Americans with low incomes which compounds the health problems of the poor who cannot afford either medical service or treatment. Grinding poverty causes some to seek relief through drugs which increases medical problems and further aggravates inequality being fed by an illicit industry that is growing in America. Drug abuse kills Americans in many ways; not the least of which is addiction and poverty.

The history of American income inequality is burdened by forms of racism and sexual discrimination that do not treat people equally.

Jobs are changing with automation and outsourcing of goods produced by an international economy. American government has failed to create policies that help those who need more help. As one of the wealthiest nations in the world, America has been incapable of solving the spread of poverty among its citizens.

In reading/listening to Desmond’s research, it seems like there is an American conspiracy making one of the wealthiest countries in the world incapable of solving the housing, education, and employment problems of its citizens.

SURVEILLANCE SOCIETY

The author makes a point in “The Dream Hotel”, but her book is a tedious repetition of the risk of human digitization that is a growing concern in this 21st century world.

Books of Interest
Website: chetyarbrough.blog

The Dream Hotel (A Novel)

By: Laila Lalami

Narrated By: Frankie Corzo, Barton Caplan

Laila Lalami (Moroccan-American novelist, essayist, and professor, earned a PhD in linguistics, finalist for the Pulitzer Prize for “The Moor’s Account”.)

Laila Lalami imagines a “Brave New World” in which algorithms predict probabilities of lethal criminal behavior. She creates a nation-state with a human behavior monitoring and detention system for every human that might commit a lethal crime. The growing collection of data about human thought and action suggests a level of truth and possibility.

Lalami creates a state that monitors, collates, and creates probability algorithms for human behavior.

To a degree, that state already exists. The difference is that the algorithms are to get people to buy things in capitalist countries and jail or murder people in authoritarian countries. One might argue America and most western countries are in the first category while Russia, and North Korea are in the second.

Lalami’s description of the detention system, like many bureaucratic organizations, is inefficient and bound by rules that defeat their ideal purpose.

A young mother named Hussein is coming back from a business trip. She is detained because of data collected on her about where she has been, what she did on her business trip, her foreign sounding name, and the kind of relationship she has with her husband and twin children. An algorithm has been created based on a profile of her life. It flags the young woman so that she has a number slightly over a probability threshold of someone who might kill their husband. Of course, this is ridiculous on its face. Whether she murders her husband or not is based on innate errors of behavioral prediction and bureaucratic confusion.

Every organization or bureaucracy staffed by human beings has a level of confusion and inefficiency that is compounded by information inaccuracy.

That does not make the organization bad or good, but it does mean, like today’s American government’s bad decisions on foreign aid or FDA bureaucracy throws the baby out with the bath water. Lalami’s point is that detention because of one’s name, family relationship, and presumed prediction for murder, based on a digitized life, is absurd. Algorithms cannot predict or explain human behavior. At best, an algorithm has a level of predictability, but life is too complex to be measured by a fictive number created by an algorithm.

The author makes a point in “The Dream Hotel”, but her book is a tedious repetition of the risk of human digitization that is a growing concern in this 21st century world.

US/CHINA

The inference one draws from Rudd’s book is that peaceful co-existence will only come from a recognition and acceptance of the cultural differences between American democratic capitalism and Chinese authoritarian capitalism.

Books of Interest
Website: chetyarbrough.blog

The Avoidable War? (The Dangers of a Catastrophic Conflict between the US and China)

By: Kevin Rudd

Narrated By: Kevin Rudd, Rafe Beckley

Kevin Rudd (Author, Australian diplomat and former politician who served as the 26th prime minister of Australia. He is fluent in Mandarin and received honors in Chinese studies from the Australian National University.)

Kevin Rudd’s title, “The Avoidable War?” is a provocative book, evidenced by its audiobook title’s question mark. The greatest part of Rudd’s book has a neutral and non-committal view that almost makes one put the book down. However, Rudd’s knowledge of the languages of Chinese and English and his many diplomatic contacts with politicians in both cultures entice one to keep listening for a solution to fundamental differences. The last chapters of Rudd’s book are enlightening and have the ring of truth but imply irreconcilable cultures that make a question mark after the title of the book correct but unsatisfying.

Spheres of Influence.

The first part of Rudd’s book puts one off because it reinforces the aggressive warlike foreign policy beliefs of China and the U.S.

Rudd emphasizes China’s military buildup and its intent to expand its sphere of influence in the Pacific theater. Xi’s intention is to expand China’s power and influence. That intent gives one a sense of impending doom. One has to put that feeling aside to get to the last chapters of the book. Rudd explains the vulnerabilities of both America and China may avoid a nuclear war and its cataclysmic consequence but not offer peace.

XI JINPING (GENERAL SECRETARY OF THE COMMUNIST PARTY OF CHINA AND PRESIDENT OF THE PEOPLE’S REPUBLIC OF CHINA.)

Rudd explains the history of Xi Jinping’s rise to power and his actions assure his continuation as the General Secretary of the Chinese Communist Party and President of the People’s Republic of China. Xi served in the People’s Liberation Army for three years, beginning in 1979. Xi earned a bachelor’s degree in chemical engineering in 1979. He pursued a Doctorate in Marxist Theory and Law while working in the government. Xi rose to power in 2012 with his appointment as General Secretary of the Chinese Communist Party. He was elected by the National People’s Congress to the Presidency in 2013.

Rudd infers Xi is a committed believer in a socialist form of communism.

The picture of Xi that Rudd creates is of a leader who acknowledges the value of economic growth while firmly believing in a classless society that melds the strength of government authoritarianism with the skills of Chinese entrepreneurs. Xi maintains the direction of China’s economic growth by eliminating any political opposition from party members or influential entrepreneurs that get in the way of authoritarian socialist communism. Rudd believes Xi will be in power for many years to come.

The tariff war started by President Trump undoubtedly troubles Xi, but one doubts it will change Xi’s international frame of mind.

History has changed since Rudd wrote his book. In contrast to Xi who will likely be President for many years, America limits the office to two terms. This is particularly relevant to the authoritarian influence of Donald Trump in the next three plus years of his second term. Xi recognizes Trump will be replaced by a different President at the end of his last term in office. There will be negotiation on the tariffs, but Trump’s position is weakened by the limit of his term in office.

The faltering reduction of income for Chinese workers and families.

As noted by Rudd, the most important issues facing Xi’s administration is the reduction of income for Chinese workers and families. The immense improvements in average incomes of families in China came from its opening to capitalism which created a more socialist form of communism. That capitalist opening increases pressure on Xi to ameliorate Trump’s U.S. tariff policy. Putting aside President Trump’s false reasoning on creating an international tariff war, one hopes Xi’s need to grow the Chinese economy will aid Trump’s negotiation on tariffs.

Much of Rudd’s book is about China’s economic growth and its intent to acquire Taiwanese territory.

As is well known, the U.S. is ambivalent about Taiwan with many Americans who say “who cares” about their fate and others who believe every nation should be free to choose their own form of government. Now that China has experienced the value of introducing capitalism to communism, Taiwan would be a valuable addition to the Chinese economy. In the history of Mao’s defeat of Chiang Kai-shek in the Chinese Civil War, Taiwan became an island nation in 1949. The nation of Taiwan was built by refugees from mainland China who chose to become an independent capitalist country that eschews communism.

CHIANG KAI-SHEK (CHAIRMAN OF THE NATIONAL GOVERNMENT OF CHINA 1943-1948)

Taiwan’s growth as a tech giant has made them a capitalist economic success. Xi undoubtedly sees the potential of Taiwan’s economic benefit to China’s faltering economy. One concludes from Rudd’s book that the history of Chiang Kai-shek’s followers and their departure from China irks Xi, both from an historical as well as economic perspective.

The primary subject of Rudd’s book is the issue of war with China.

What Rudd is driving for is a rational appreciation of what America should do with the growing international power of China. Rudd implies China will become the equal, if not superior, of the American economy. He believes China will return to its former hegemonic influence, like that of its former dynasties. Rudd acknowledges Xi faces the immense task of returning China’s economy to its recent economic success. He implies Xi will succeed by carrying on with his view of how economic success can be returned with prudent authoritarian control of capitalism with the objective of creating a classless society idealized by communism.

The fundamental point Rudd is making is that China has a culture founded on authoritarianism and chooses to use capitalism in a way that is not democratic.

The surveillance technology of today allows Xi and future China rulers to influence Chinese culture in ways beyond the theoretical interest of democratic governments. The inference one draws from Rudd’s book is that peaceful co-existence will only come from a recognition and acceptance of the cultural differences between American democratic capitalism and Chinese authoritarian capitalism.

MEDICINE

A government designed to use public funds to pick winners and losers in the drug industry threatens human health. Only with the truth of science discoveries and honest reporting of drug efficacy can a physician offer hope for human recovery from curable diseases.

Books of Interest
Website: chetyarbrough.blog

Rethinking Medications (Truth, Power, and the Drugs You Take)

By: Jerry Avorn

Narrated By: Jerry Avorn MD

Jerry Avorn (Author, professor of medicine at Harvard Medical School where he received his MD, Chief Emeritus of the Division of Pharmacoepidemiology and Pharmacoeconomics)

Doctor Avorn enlightens listener/readers about drug industry’ costs, profits, and regulation. Avorn explains how money corrupts the industry and the FDA while encouraging discovery of effective drug treatments. The cost, profits, and benefits of the industry revolve around research, discovery, medical efficacy, human health, ethics, and regulation.

Drug manufacture is big business.

Treatments for human maladies began in the dark ages when little was known about the causes of disease and mental dysfunction. Cures ranged from spirit dances to herbal concoctions that allegedly expelled evil, cured or killed its followers and users. The FDA (Food and Drug Administration) did not come into existence until 1930, but its beginnings harken back to the 1906 Pure Food and Drug Act signed into law by Theodore Roosevelt. The FDA took on the role of reviewing scientific drug studies for drug treatments that could aid health recovery for the public. The importance of review was proven critical by incidents like that in 1937, when 107 people died from a Sulfanilamide drug which was found to be poisonous. From that 1937 event forward, the FDA required drug manufacturers to prove safety of a drug before selling it to the public. The FDA began inspecting drug factories while demanding drug ingredient labeling. However, Avorn illustrates how the FDA was seduced by Big Pharma’ to offer drug approvals based on flawed or undisclosed research reports.

Dr. Martin Makary (Dr. Makary was confirmed as the new head of the FDA on March 25, 2025. He is the 27th head of the Department. He is a British-American surgeon and professor.)

What Dr. Avorn reveals is how the FDA has either failed the public or been seduced by drug manufacturers to approve drugs that have not cured patients but have, in some cases, harmed or killed patients. It will be interesting to see what Dr. Marin Makary can do to improve FDA’s regulation of drugs. Avorn touches on court cases that have resulted in huge financial settlements by drug manufacturing companies and their stockholders. However, he notes the actual compensation received by individually harmed patients or families is miniscule in respect to the size of the fines; not to mention many billions of dollars the drug companies received before unethical practices were exposed. Avorn notes many FDA’ research and regulation incompetencies allowed drug companies to hoodwink the public about drug companies’ discovered but unrevealed drug side-effects.

A few examples can be easily found in an internet search:

1) Vioxx (Rofecoxib), a pain killer, had to be withdrawn from use in 2004 because it was linked to increased risk of heart attacks and strokes. It was removed from the market in 2004.

2) Fen-Phen (Fenfluramine/Phentermine), a weight-loss drug had to be taken off the market in 1997 because of severe heart and lung complications.

3) Accutane was used to cure acne but was found to be linked to birth defects and had to be withdrawn in 2009.

4) Thalidomide was found to cause birth defects to become repurposed for treatment of certain cancers.

5) A more recent failure of the FDA is their failure to regulate opioids like OxyContin that resulted in huge fines to manufacturers and distributors of the drug.

Lobbyists are hired by drug companies to influence politicians to gain support of drug companies. In aggregate, this chart shows the highest-spending lobbyists in the 3rd Qtr. of 2020 were in the medical industry.

Dr. Avorn argues Big Pharma’s lobbying power has unduly influenced FDA to approve drugs that are not effective in treating patients for their diagnosed conditions. Avorn infers Big Pharma is more focused on increasing revenue than effectively reviewing drug manufacturer’ supplied studies. Avorn argues the FDA has become too dependent on industry fees that are paid by drug manufacturers asking for expedited drug approvals. Avorn infers the FDA fails to demand more documentation from drug manufacturers on their drug’ research. The author suggests many approved opioids, cancer treatment drugs, and psychedelics have questionable effectiveness or have safety concerns. Misleading or incomplete information is provided by drug companies that makes applications an approval process, not a fully relevant or studied action on the efficacy of new drugs.

Avorn is disappointed in the Trump administrations’ selection of Robert Kennedy as the U.S. Secretary of Health and Human Services because of his lack of qualification.

The unscientific bias of Kennedy and Trump in regard to vaccine effectiveness reinforces the likelihood of increased drug manufacturers’ fees that are just a revenue source for the FDA. Trump will likely reward Kennedy for decreasing the Departments’ overhead by firing research scientists and increasing the revenues they collect from drug manufacturers seeking drug approvals.

Trump sees and uses money as the only measure of value in the world.

It is interesting to note that Avorn is a Harvard professor, a member of one of the most prestigious universities in the world. Harvard is being denied government grants by the Trump administration, allegedly because of Harvard’s DEI policy. One is inclined to believe diversity, equity, and inclusion are ignored by Trump because he is part of the white ruling class in America. Trump chooses to stop American aid to the world to reduce the cost of government. American government’s decisions to starve the world and discriminate against non-whites is a return to the past that will have future consequences for America.

Next, Avorn writes about the high cost of drugs, particularly in the United States. Discoveries are patented in the United States to incentivize innovation, but drug companies are gaming that Constitutional right by slightly modifying drug manufacture when their patent rights are nearing expiration. They renew their patent and control the price of the slightly modified drug that has the same curative qualities. As publicly held corporations, they are obligated to keep prices as high as the market allows. The consequence leaves many families at the mercy of their treatable diseases because they cannot afford the drugs that can help them.

Martin Shkreli, American investor who rose to fame and infamy for using hedge funds to buy drug patents and artificially raise their prices to only increase revenues.

The free market system in America allows an investor to buy a drug patent and arbitrarily raise its price. Avorn suggests this is a correctable problem with fair regulation and a balance between government sponsored funding for drug research in return for public funding. Of course, there are some scientists like Jonas Salk in 1953 who refused to privately patent the polio vaccine because it had such great benefit to the health of the world.

Avorn notes the 1990’s drug costs in the U.S. are out of control.

Only the rich are able to pay for newer drugs that cost hundreds of thousands of dollars per year. Americans spend over $13,000 per year per person while Europe is around $5,000 and low-income countries under $500 per year. These expenditures are to extend life which one would think make Americans live longest. Interestingly, America is not even in the top 10. Hong Kong’s average life expectancy is 85.77 years, Japan 85. South Korea 84.53. The U.S. average life expectancy is 79.4. To a cynic like me, one might say what’s 5 or 6 more years of life really worth? On the other hand, billionaires and millionaires like Peter Thiel and Bryan Johnson have invested millions into anti-aging research.

Avorn reinforces the substance of Michael Pollan’s book “How to Change Your Mind” which reenvisions the value of hallucinogens in this century.

Avorn notes hallucinogens efficacy is reborn in the 21st century to a level of medical and social acceptance. Avorn is a trained physician as opposed to Pollan who is a graduate with an M.A. in English, not with degrees in science or medicine.

In reviewing Avorn’s informative history, it is apparent that patients should be asking their doctors more questions about the drugs they are taking.

Drugs have side effects that can conflict with other drugs being taken. In this age of modern medicine, there are many drugs that can be effective, but they can also be deadly. Drug manufacturers looking at drug creation as only revenue producers is a bad choice for society.

Avorn’s history of the drug industry shows failure in American medicines is more than the mistake of placing an incompetent in charge of the U.S.

Taking money away from research facilities diminishes American innovation in medicine and other important sciences. However, research is only as good as the accuracy of its proof of efficacy for the treatment of disease and the Hippocratic Oath of “First, do no harm”. A government designed to use public funds to pick winners and losers in the drug industry threatens human health. Only with the truth of science discoveries and honest reporting of drug efficacy can a physician offer hope for human recovery from curable diseases.

PROJECT 2025

Only the Constitution of the United States stands between Trump’s authoritarianism and what has made America one of the wealthiest countries in the world.

Books of Interest
Website: chetyarbrough.blog

The Project (How Project 2025 Is Reshaping America)

By: David A. Graham

Narrated By: Ari Fliakos

David A. Graham (Author, journalist, staff writer at The Atlantic.)

Graham has taken the time to dissect the policies proposed by the Heritage Foundation’s support and creation of Project 2025. Project 2025 is a political treatise that seems to outline many of the policies and objectives of the Trump administration.

As Graham notes, even though Trump is unlikely to have read Project 2025, its content seems to outline much of what Trump has done or is trying to do in his Presidency.

A priority in Project 2025 is downsizing the federal government. Interestingly, government employee firings began as soon as Trump entered the oval office. With Trump’s appointment of Elon Musk as the leader of DOGE (the Department of Government Efficiency) over 200,000 federal workers have been discharged. An estimated 10,000 employees were discharged from the Department of Health and Human Services. If all of these firings were to be permanent, an estimated $1.17 billion to $1.26 billion would be saved per year. With 2 million federal employees, less than 1 percent of the payroll cost of government has been SAVED.

Three things come to mind with the 1 percent cost reduction in government employee payroll.

One, is the effect of a job lost to a family who depends on gainful employment. Two, what public services are lost as a result of 2oo,000 fired government employees. And finally, what value is there to the public in reducing government payroll cost by less than 1 percent?

Of course, some will say that misses the point of the symbolic value of reducing the cost of government.

After all, America is founded on capitalism not socialist welfare. Yes and no. Yes, we are capitalists. No, we benefit from government employees who are gainfully employed because they buy things with the money they make while providing service to the public. Is the risk of unemployment in America worth the cost of some human inefficiency?

Project 2025 recommends tax system overhaul with the implementation of a flat income tax.

Trump has reduced jobs in the Department of the IRS. One should remind oneself that the present tax system takes the same maximum amount of money per year out of a family’s income for social security whether they make a million dollars per year or minimum wage. The social security tax rate is 6.2% of up to $176,100 of income per year. After one who is making more than $176,100, no further social security tax is taken. Americans pay that 6.2% whether they make minimum wage or millions of dollars per year. There is something wrong with that picture. Tax reform is needed in America, but the tax reform Trump is interested in is for rich capitalists, not minimum wage earners.

Trump wants to abolish the IRS and finance the government with tariffs and a sales tax.

He wants to have a national sales tax of 23% or roughly 30 cents per dollar spent. That tax will be a burden to the poor but nothing to the rich. Trump perceives an equal benefit to minimum wage workers because they would not have to pay taxes on tips, overtime, and social security. Is that tax benefit equal to corporate tax reductions of 21% to 20% and a reduced rate of 15% for U.S. manufacturers. More jobs may or may not be created, but who gains the most benefit?

Trump infers corporation owners and managers would not put tax savings in their pockets but would create more jobs.

Two entitlement programs Trump believes will be unnecessary as a result of his tax changes are Medicare and Medicaid. Trump supporters believe economic growth will offset the negative impact that his tax reform plan will have on the poor. Does that make it unnecessary to have Medicare or Medicaid for the poor?

Trump is making a mockery of the Constitution by indiscriminately arresting and deporting anyone who cannot prove their status as a legal resident of America.

Project 2025 insists on immigration enforcement with improved border security and tighter immigration policies. Trump endorses that plan, but it is a job for Congress, not an autocratic President. He is willing to pay immigrants with American tax dollars for them to return to their countries of birth. Whose money is it that Trump is choosing to use?

Trump believes global warming is just a seasonal event in the history of earth.

Project 2025 recommends rolling back environmental regulations and endorsing fossil fuels over renewable energy. Trump endorses that plan by rolling back environmental regulations because he believes global warming is a fiction. Science is a fiction to President Trump.

Project 2025 recommends strengthening the executive branch of government and decreasing the rolls of Congress and the courts.

Project 2025 recommends strengthening the executive branch of government and decreasing the rolls of Congress and the courts that are the basis upon which separation of powers were written into the Constitution. Trump is ignoring fundamental tenants of the Constitution like Due Process of Law in the deportation of immigrants.

Project 2025 recommends criminalizing pornography, removing legal protections for anti-LGBT discrimination, and ending diversity programs that drive for equality of all Americans. Trump is using the office of the Presidency to punish elite colleges that have DEI programs meant to address American social inequality.

Trump believes what he believes and acts on those beliefs. His sexual picadilloes are ok but pornography is not. The author shows Trump has support for his beliefs in Project 2025. His support is equally apparent in the free vote of a majority who voted for him in the last election. Only the Constitution of the United States stands between Trump’s authoritarianism and what has made America one of the wealthiest countries in the world.

RISK/REWARD

AI is only a tool of human beings and will be misused by some leaders in the same way Atom bombs, starvation, disease, climate, and other maladies have harmed the sentient world. AI is more of an opportunity than threat to society.

Books of Interest
Website: chetyarbrough.blog

A Brief History of Artificial Intelligence (What It Is, Where We Are, and Where We Are Going)

By: Michael Wooldridge

Narrated By: Glen McCready

Michael Wooldridge (Author, British professor of Computer Science, Senior Research Fellow at Hertford College University of Oxford.)

Wooldridge served as the President of the International Joint Conference in Artificial Intelligence from 2015-17, and President of the European Association for AI from 2014-16. He received a number of A.I. related service awards in his career.

Alan Turing (1912-1954, Mathematician, computer scientist, cryptanalyst, philosopher, and theoretical biologist.)

Wooldridge’s history of A.I. begins with Alan Turing who has the honorific title of “father of theoretical computer science and artificial intelligence”. Turing is best known for breaking the German Enigma code in WWII with the development of an automatic computing engine. He went on to develop the Turing test that evaluated a machine’s ability to provide answers to questions that exhibited human-like behavior. Sadly, he is equally well known for being a publicly persecuted homosexual who committed suicide in 1954. He was 41 years old at the time of his death.

Wooldridge explains A.I. has had a roller-coaster history of highs and lows with new highs in this century.

Breaking the Enigma code is widely acknowledged as a game changer in WWII. Enigma’s code breaking shortened the war and provided strategic advantage to the Allied powers. However, Wooldridge notes computer utility declined in the 70s and 80s because applications relied on laborious programming rules that introduced biases, ethical concerns, and prediction errors. Expectations of A.I.’s predictability seemed exaggerated.

The idea of a neuronal connection system was thought of in 1943 by Warren McCulloch and Walter L Pitts.

In 1958, Frank Rosenblatt developed “Perception”, a program based on McCulloch and Pitt’s idea that made computers capable of learning. However, this was a cumbersome programming process that failed to give consistent results. After the 80s, machine learning became more usefully predictive with Geoffrey Hinton’s devel0pment of backpropagation, i.e., the use of an algorithm to check on programming errors with corrections that improved A.I. predictions. Hinton went on to develop a neural network in 1986 that worked like the synapse structure of the brain but with much fewer connections. A limited neural network for computers led to a capability for reading text and collating information.

Geoffrey Hinton (the “Godfather of AI” won the 2018 Turing Award.)

Then, in 2006 Hinton developed a Deep Belief Network that led to deep learning with a type of a generative neural network. Neural networks offered more connections that improved computer memory with image recognition, speech processing, and natural language understanding. In the 2000s, Google acquired a deep learning company that could crawl and index the internet. Fact-based decision-making, and the accumulation of data, paved the way for better A.I. utility and predictive capability.

Face recognition capability.

What seems lost in this history is the fact that all of these innovations were created by human cognition and creation.

Many highly educated and inventive people like Elon Musk, Stephen Hawking, Bill Gates, Geoffrey Hinton, and Yuval Harari believe the risks of AI are a threat to humanity. Musk calls AI a big existential threat and compares it to summoning a demon. Hawking felt Ai could evolve beyond human control. Gates expressed concern about job displacement that would have long-term negative consequences with ethical implications that would harm society. Hinton believed AI would outthink humans and pose unforeseen risks. Harari believed AI would manipulate human behavior and reshape global power structures and undermine governments.

All fears about AI have some basis for concern.

However, how good a job has society done throughout history without AI? AI is only a tool of human beings and will be misused by some leaders in the same way atom bombs, starvation, disease, climate, and other maladies have harmed the sentient world. AI is more of an opportunity than threat to society.

FUTURE A.I.

Human nature will not change but A.I. will not destroy humanity but insure its survival and improvement.

Books of Interest
Website: chetyarbrough.blog

Human Compatible (Artificial Intelligence and the Problem of Control)

By: Stuart Russell

Narrated By: Raphael Corkhill

Stuart Johnathan Russell (British computer scientist, studied physics at Wadham College, Oxford, received first-class honors with a BA in 1982, moved to U.S. and received a PhD in computer science from Stanford.)

Stuart Russell has written an insightful book about A.I. as it currently exists with speculation about its future. Russell in one sense agrees with Marcus’s and Davis’s assessment of today’s A.I. He explains A.I. is presently not intelligent but argues it could be in the future. The only difference between the assessments in Marcus’s and Davis’s “Rebooting AI” and “Human Compatible” is that Russell believes there is a reasonable avenue for A.I. to have real and beneficial intelligence. Marcus and Davis are considerably more skeptical than Russell about A.I. ever having the equivalent of human intelligence.

Russell infers A.I. is at a point where gathered information changes human culture.

Russell argues A.I. information gathering is still too inefficient to give the world safe driverless cars but believes it will happen. There will be a point where fewer deaths on the highway will come from driverless cars than those that are under the control of their drivers. The point is that A.I. will reach a point of information accumulation that will reduce traffic deaths.

A.I. will reach a point of information accumulation that will reduce traffic deaths.

After listening to Russell’s observation, one conceives of something like a pair of glasses on the face of a person being used to gather information. That information could be automatically transferred by improvements in Wi-Fi to a computing device that would collate what a person sees to become a database for individual human thought and action. The glasses will become a window of recallable knowledge to its wearer. A.I. becomes a tool of the human mind which uses real world data to choose what a human brain comprehends from his/her experience in the world. This is not exactly what Russell envisions but the idea is born from a combination of what he argues is the potential of A.I. information accumulation. The human mind remains the seat of thought and action with the help of A.I., not the direction or control by A.I.

Russell’s ideas about A.I. address the concerns that Marcus and Davis have about intelligence remaining in the hands of human’s, not a machine that becomes sentient.

Russell agrees with Marcus, and Davis–that growth of A.I. does have risk. However, Russell goes beyond Marcus and Davis by suggesting the risk is manageable. Risk management is based on understanding human action is based on knowledge organized to achieve objectives. If one’s knowledge is more comprehensive, thought and action is better informed. Objectives can be more precisely and clearly formed. Of course, there remains the danger of bad actors with the advance of A.I., but that has always been the risk of one who has knowledge and power. The minds of a Mao, Hitler, Beria, Stalin, and other dictators and murderers of humankind will still be among us.

The competition and atrocities of humanity will not disappear with A.I. Sadly, A.I. will sharpen the dangers to humanity but with an equal resistance by others that are equally well informed. Humanity has managed to survive with less recallable knowledge so why would humanity be lost with more recallable knowledge? As has been noted many times in former book reviews, A.I. is, and always will be, a tool of human beings, not a controller.

The world will have driverless cars, robotically produced merchandise, and cultures based on A.I.’ service to others in the future.

Knowledge will increase the power and influence of world leaders to do both good and bad in the world. Human nature will not change but A.I. will not destroy humanity. Artificial Intelligence will insure human survival and improvement. History shows humanity has survived famine, pestilence, and war with most cultures better off than when human societies came into existence.

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